COMBIBASE |
About Combibase Eukaryotes during their development and differentiation integrate a wide range of tissue, developmental and environmental signals to regulate complex patterns of gene expression. A major level at which gene expression is regulated is the initiation of transcription. Wide spectrum of expression patterns are achieved by the discrete use of combinations of transcription factors which is otherwise called as the combinatorial transcription control. The regulation of expression of a gene by a combination of transcription factors depend on the presence of conserved transcription factor binding sites in the promoters of eukaryotic genes. This in combination with the availability of whole genome sequences facilitate in silico analysis of eukaryotic gene promoters for combinatorial transcription control. To make this task easy "COMBIBASE" has been developed by the Molecular Biology and Bioinformatics group of the Centre for Plant Molecular Biology, Osmania University, Hyderabad 500 007, Andhra Pradesh, INDIA. In the current version (version-1) 20,000 genes of Arabidopsis thaliana are included and the future versions shall include Rice, Human and Mouse genes. What is Combinatorial Control Combinatorial control is the use of discrete number of transcriptional factors in different combinations to give rise to a wide spectrum of expression patterns. It allows expression of a gene to be modulated by multiple ligands - Singh. KB (1998, Plant Physiology 118: 11111-1120) About the authors A.snehalatharani, Mubarak begum, M.Shashikanth are the research scholars working at CPMB, Osmania University and their contribution to this work is in the order given. Mr. A.Sudhakar is the programer and K.Ulaganathan is the Group Leader and Associate Professor at CPMB, Osmania University. |